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Company Analysis

Spyre Therapeutics, Inc. SYRE

A comprehensive view of key metrics, scores, and financial health for Spyre Therapeutics, Inc.

Overview of Spyre Therapeutics, Inc.

SYRE NMS
Healthcare Biotechnology Mid Cap
Spyre Therapeutics, Inc. (SYRE), is a Mid Cap company, in the Biotechnology industry, last closed at $39.89, about 0.0% overvalued vs fair value, +115.2% 1Y return, ranked 312/1110 in sector.
$39.89
-1.29%
As of March 13, 2026
Previous close • Vol 90d: 57.1%
52-Week Range
Market Cap
$3.15B
Enterprise Value
$3.15B
Overall Score
Scores locked

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Top Beats
No strong beats yet

Quick Facts

Website https://www.spyre.com
HQ Waltham, MA
Employees 102
Fiscal year Dec 31

Next Events

Earnings May 7 Estimated

Fair Value Snapshot

Insufficient data
Show more details
  • Revenue data missing or non-positive

Engine Room Money Flow™

Mid Cap

Biotech / Pre-Revenue - Where revenue goes and how value is created

Flow Steps
Cash on Hand
$85.7M
-4.1%%
Total Revenue
$0
Net Income
$-155.2M
25.4%%
Operating Expense
$219.6M
5.3%%
Money Flow Bridge
Flow Direction: Money moves from left to right
Components: Breakdown shows composition of each stage
Industry-Specific: Biotech / Pre-Revenue

Quality & Reliability Indicators

Cash Runway
6.1 months
Poor

Critical: Cash runway under 12 months

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Where It Leaks

Cash Flow Health healthy
Strong cash conversion with minimal leakage across profit-to-cash-to-value chain.
0
Active Leaks
0/0
Improving
0
High Impact
0
Critical
Moat Analysis Corporate Default

Competitive Advantage Assessment

Evaluating Spyre Therapeutics, Inc.'s durable competitive advantages across 6 defense dimensions

Overall Moat Strength
29
/100
Developing
Scores based on quantitative metrics and qualitative factors

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Pricing Power

Weak
16
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Trade-Off Ledger

Where management spends the performance budget

Insufficient Data for Analysis

SYRE - Spyre Therapeutics, Inc.

We have limited financial data for SYRE. The Growth and Profitability axes don't have enough metrics for reliable analysis.

Data Coverage by Axis

Growth
0% coverage Below threshold
Profitability
0% coverage N/A
Overall Coverage: 26.7% (Minimum 40% required)

What This Means

  • Currently at 26.7% data coverage (minimum 40% required)
  • Limited peer data available for industry benchmarking
  • Check back after quarterly or annual filings
  • Some metrics may not be applicable to this company's business model

What can you do?

  • View available sections like Moat Map or Engine Room for partial insights
  • Set up a watchlist alert to be notified when new data becomes available
  • Compare with peers in the same industry that have complete data

Two Futures

Scenario-based fair value ranges for Spyre Therapeutics, Inc..

Loading valuation model...
Unable to Compute Fair Value

This company cannot be valued using standard models.

What this means: The Scenario Theatre requires financial data (revenue, cash flow, shares outstanding) to calculate fair value estimates. This data may be unavailable for:

  • Recently listed companies (IPOs, SPACs)
  • Shell companies or holding companies
  • Companies that haven't filed recent financials
  • Foreign companies with limited data coverage
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Fair Value Range Current: $-
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