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Company Analysis

Ionis Pharmaceuticals, Inc. IONS

A comprehensive view of key metrics, scores, and financial health for Ionis Pharmaceuticals, Inc.

Overview of Ionis Pharmaceuticals, Inc.

IONS NMS
Healthcare Biotechnology Large Cap
Ionis Pharmaceuticals, Inc. (IONS), is a Large Cap company, in the Biotechnology industry, last closed at $71.78, about 88.8% overvalued vs fair value, +133.7% 1Y return, ranked 309/1121 in sector.
Metrics Rev Growth 33.9% ROE -70.7% Gross Margin 98.3%
$71.78
-0.62%
As of April 28, 2026
Previous close • Vol 90d: 29.6%
52-Week Range
Market Cap
$11.86B
Enterprise Value
$14.31B
Overall Score
View breakdown
Overall
Growth
Fair
Profitability
Good
Health
Good
Efficiency
Fair
Valuation
Fair
Growth
Fair
Profitability
Good
Health
Good
Efficiency
Fair
Valuation
Fair
Completeness: 82%
Confidence: 54%
Updated: Mar 8
Top Beats

Quick Facts

Website https://www.ionis.com
HQ Carlsbad, CA
Employees 1,069
Fiscal year Dec 31

Next Events

Earnings May 6 Estimated

Fair Value Snapshot

Bear Base Bull
$7
$8
$9
Current: $71.78 -89% vs base

Engine Room Money Flow™

Large Cap

Biotech / Pre-Revenue - Where revenue goes and how value is created

Flow Steps
Cash on Hand
$372.3M
53.8%%
Total Revenue
$944.0M
33.9%%
Net Income
$-381.0M
16.1%%
Operating Expense
$1.3B
12.1%%
Money Flow Bridge
Flow Direction: Money moves from left to right
Components: Breakdown shows composition of each stage
Industry-Specific: Biotech / Pre-Revenue

Quality & Reliability Indicators

Cash Runway
16.6 months
Fair

Limited runway, likely needs financing within a year

Locked Metric
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Owner's Pocket - Capital Allocation

Total Returned to Shareholders

Combined dividends, buybacks, and debt reduction

$11.0M
2.9% of Cash on Hand

Where It Leaks

Cash Flow Health healthy
Strong cash conversion with minimal leakage across profit-to-cash-to-value chain.
0
Active Leaks
0/0
Improving
0
High Impact
0
Critical
Moat Analysis Corporate Default

Competitive Advantage Assessment

Evaluating Ionis Pharmaceuticals, Inc.'s durable competitive advantages across 6 defense dimensions

Overall Moat Strength
70
/100
Moderate
Scores based on quantitative metrics and qualitative factors

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Pricing Power

Strong
80
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Trade-Off Ledger

Where management spends the performance budget

Insufficient Data for Analysis

IONS - Ionis Pharmaceuticals, Inc.

We have limited financial data for IONS. The Growth and Profitability axes don't have enough metrics for reliable analysis.

Data Coverage by Axis

Growth
0% coverage Below threshold
Profitability
0% coverage N/A
Overall Coverage: 33.3% (Minimum 40% required)

What This Means

  • Currently at 33.3% data coverage (minimum 40% required)
  • Limited peer data available for industry benchmarking
  • Check back after quarterly or annual filings
  • Some metrics may not be applicable to this company's business model

What can you do?

  • View available sections like Moat Map or Engine Room for partial insights
  • Set up a watchlist alert to be notified when new data becomes available
  • Compare with peers in the same industry that have complete data

Two Futures

Scenario-based fair value ranges for Ionis Pharmaceuticals, Inc..

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Unable to Compute Fair Value

This company cannot be valued using standard models.

What this means: The Scenario Theatre requires financial data (revenue, cash flow, shares outstanding) to calculate fair value estimates. This data may be unavailable for:

  • Recently listed companies (IPOs, SPACs)
  • Shell companies or holding companies
  • Companies that haven't filed recent financials
  • Foreign companies with limited data coverage
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Bear
-
- - -
- upside
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Base
$8.04
- - -
-88.8% vs current
Snapshot base estimate
Bull
-
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- upside
-
Fair Value Range Current: $-
$- $- $-
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