Aprea Therapeutics, Inc. APRE

Competitive advantage analysis · healthcare

Corporate Default
Overall moat score
32/100
Developing

Ranked against 712 peers in Biotechnology

About Aprea Therapeutics, Inc.

Aprea Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing novel synthetic lethality-based cancer therapeutics that targets DNA damage response pathways. Its lead product candidates are APR-1051, an orally bioavailable small-molecule inhibitor of WEE1 kinase that is in Phase 1 clinical trial for the treatment of patients with advanced solid tumors with biomarkers; and ATRN-119, an ATR inhibitor, … Full APRE analysis →

Key risks

  • ROIC Below WACC or Peers ROIC at 30.2th percentile suggests inefficient capital deployment.
  • Elevated Debt Risk Debt serviceability is weak (score 0.36), raising refinancing risk.

The dashed ring is the peer median. Defense scores are percentile ranks against peers, so 50 is roughly the typical company in this group.

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Pricing Power

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Signals, strengths and risks for Pricing Power

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Signals, strengths and risks for Cost Advantage

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Signals, strengths and risks for Customer Stickiness

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Signals, strengths and risks for Capital Efficiency

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Signals, strengths and risks for Resilience

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Signals, strengths and risks for Scale & Market Position

Where APRE ranks in Biotechnology

Aprea Therapeutics, Inc. ranks #486 of 713 scored companies in Biotechnology by moat score — the top 68%. The widest moat in the group is Royalty Pharma plc (RPRX) at 85/100.

# Company Moat score Rating
482 Immix Biopharma, Inc. IMMX 32/100 Developing
483 Innate Pharma S.A. IPHA 32/100 Developing
484 Inventiva S.A. - American Depos IVA 32/100 Developing
485 Roivant Sciences Ltd. ROIV 32/100 Developing
486 Aprea Therapeutics, Inc. APRE 32/100 Developing
487 Athira Pharma, Inc. ATHA 32/100 Developing
488 Lipella Pharmaceuticals Inc. LIPO 32/100 Developing
489 Sana Biotechnology, Inc. SANA 32/100 Developing
490 Absci Corporation ABSI 32/100 Developing

See every Biotech / Pre-Revenue company ranked by moat score →

How APRE scores on the Corporate Default defenses

Pricing Power

Not measurable · 20% of the moat score

Pricing power is the ability to raise prices without losing volume.

Cost Advantage

Not measurable · 15% of the moat score

A cost advantage means delivering the same product for structurally less — better purchasing, denser distribution, a more automated process.

Customer Stickiness

Not measurable · 15% of the moat score

Stickiness is what makes revenue repeat without being re-won every year.

Capital Efficiency

Score 24 · 18% of the moat score

Capital efficiency asks what the company earns on the money tied up in the business.

Resilience

Score 44 · 17% of the moat score

Resilience is the capacity to get through a bad year on its own terms — enough liquidity, enough interest cover, and enough cash generation to avoid a rescue financing or a forced sale.

Scale & Market Position

Not measurable · 15% of the moat score

Scale matters only when it converts into economics.

How each Corporate Default defense is measured, in full →

Understanding APRE's moat

What is Aprea Therapeutics, Inc.'s moat score?

Aprea Therapeutics, Inc. (APRE) scores 32 out of 100 on the StatsAlpha Moat Map, which rates its competitive advantage as developing. It ranks #486 of 713 scored companies in Biotechnology, the top 68%. The score is a weighted composite of 6 competitive defenses, each measured against industry peers of 712 companies in Biotechnology. Its strongest defense is Resilience (44/100) and its weakest is Capital Efficiency (24/100).

How does Aprea Therapeutics, Inc. compare with other Biotechnology companies?

Aprea Therapeutics, Inc. ranks #486 of 713 scored companies in Biotechnology by moat score. The widest moat in Biotechnology is Royalty Pharma plc (RPRX) at 85/100. The companies ranked closest are Roivant Sciences Ltd. (ROIV) at 32 just above it and Athira Pharma, Inc. (ATHA) at 32 just below it.

How is the moat score calculated?

Each company is scored with an industry-specific template — Corporate Default in this case, chosen because the defenses that matter to a bank are not the ones that matter to a software company. Every defense combines several financial signals, and each signal is measured as a percentile against a peer group of 712 companies in Biotechnology. The defenses are then weighted to produce the overall score out of 100.

Why is Aprea Therapeutics, Inc. scored with the Corporate Default template?

Most public companies sell a product or a service at a margin, so the moat question is whether that margin survives contact with competitors. The Corporate template scores the six defenses that show up in a general operating company's financial signature: whether it can hold price, produce more cheaply than rivals, keep its customers, earn a return above its cost of capital, withstand a downturn, and turn size into economics.

Which competitive defenses are measured for Aprea Therapeutics, Inc.?

The Corporate Default template measures 6 defenses, and APRE scores: Pricing Power (not measurable), Cost Advantage (not measurable), Customer Stickiness (not measurable), Capital Efficiency (24), Resilience (44), Scale & Market Position (not measurable). Each is scored independently as a percentile against peers, so a company can be strong on one and weak on another — the overall score reflects how those defenses are weighted for this industry.

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