Carisma Therapeutics, Inc., a biotechnology company, focuses on developing transformative therapies to treat liver fibrosis and cancer in the United States. Its product candidates include CT-2401, which is in preclinical trial for the treatment of liver fibrosis. The company also develops CT-1119, a mesothelin-targeted CAR-Monocyte that is in phase I clinical trial to treat patients with advanced mesothelin-positive solid tumors, …
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Competitive advantage assessment
Key strengths
ROIC Sustainably Above PeersROIC at 95.2th percentile exceeds peers and WACC, demonstrating superior capital allocation.
Margins Stable Across CyclesOperating margin volatility is low (stability score 0.76), demonstrating pricing resilience across cycles.
Key risks
Liquidity ConcernsLiquidity is concerning (score 0.17), raising questions about short-term obligations.
Carisma Therapeutics, Inc. ranks #236 of 713
scored companies in Biotechnology by moat score — the top 33%.
The widest moat in the group is Royalty Pharma plc (RPRX)
at 85/100.
Moat scores for companies ranked near CARM in Biotechnology
Pricing power is the ability to raise prices without losing volume.
Cost Advantage
Score 60
· 15% of the moat score
A cost advantage means delivering the same product for structurally less — better purchasing, denser distribution, a more automated process.
Customer Stickiness
Score 59
· 15% of the moat score
Stickiness is what makes revenue repeat without being re-won every year.
Capital Efficiency
Score 67
· 18% of the moat score
Capital efficiency asks what the company earns on the money tied up in the business.
Resilience
Score 39
· 17% of the moat score
Resilience is the capacity to get through a bad year on its own terms — enough liquidity, enough interest cover, and enough cash generation to avoid a rescue financing or a forced sale.
Scale & Market Position
Score 38
· 15% of the moat score
Scale matters only when it converts into economics.
Carisma Therapeutics, Inc. (CARM) scores 50 out of 100 on the StatsAlpha Moat Map, which rates its competitive advantage as moderate. It ranks #236 of 713 scored companies in Biotechnology, the top 33%. The score is a weighted composite of 6 competitive defenses, each measured against industry peers of 712 companies in Biotechnology. Its strongest defense is Capital Efficiency (67/100) and its weakest is Scale & Market Position (38/100).
How does Carisma Therapeutics, Inc. compare with other Biotechnology companies?
Carisma Therapeutics, Inc. ranks #236 of 713 scored companies in Biotechnology by moat score. The widest moat in Biotechnology is Royalty Pharma plc (RPRX) at 85/100. The companies ranked closest are Insmed Incorporated (INSM) at 51 just above it and Merus N.V. (MRUS) at 50 just below it.
How is the moat score calculated?
Each company is scored with an industry-specific template — Corporate Default in this case, chosen because the defenses that matter to a bank are not the ones that matter to a software company. Every defense combines several financial signals, and each signal is measured as a percentile against a peer group of 712 companies in Biotechnology. The defenses are then weighted to produce the overall score out of 100.
Why is Carisma Therapeutics, Inc. scored with the Corporate Default template?
Most public companies sell a product or a service at a margin, so the moat question is whether that margin survives contact with competitors. The Corporate template scores the six defenses that show up in a general operating company's financial signature: whether it can hold price, produce more cheaply than rivals, keep its customers, earn a return above its cost of capital, withstand a downturn, and turn size into economics.
Which competitive defenses are measured for Carisma Therapeutics, Inc.?
The Corporate Default template measures 6 defenses, and CARM scores: Pricing Power (41), Cost Advantage (60), Customer Stickiness (59), Capital Efficiency (67), Resilience (39), Scale & Market Position (38). Each is scored independently as a percentile against peers, so a company can be strong on one and weak on another — the overall score reflects how those defenses are weighted for this industry.
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