Coya Therapeutics, Inc. COYA

Competitive advantage analysis · healthcare

Corporate Default
Overall moat score
49/100
Developing

About Coya Therapeutics, Inc.

Coya Therapeutics, Inc., a clinical-stage biotechnology company, develops proprietary therapies to enhance the function of regulatory T cells (Tregs). The company's product candidate pipeline is based on therapeutic modalities, such as Treg-enhancing biologics, Treg-derived exosomes, and autologous Treg cell therapy. It develops COYA 302, a biologic combination for subcutaneous administration intended to enhance Treg function while depleting T effector function … Full COYA analysis →

Competitive advantage assessment

Key strengths

  • Strong Interest Coverage & Conservative Leverage Debt serviceability is strong (score 0.81), with robust interest coverage.
  • Margins Stable Across Cycles Operating margin volatility is low (stability score 0.77), demonstrating pricing resilience across cycles.

Key risks

  • Scale Without Profitability Despite scale, profitability lags peers (score 0.35), suggesting limited competitive advantage.
  • Revenue Volatility Signals Weak Stickiness Revenue volatility is high (stability score 0.00), suggesting weak customer stickiness.

The dashed ring is the peer median. Defense scores are percentile ranks against peers, so 50 is roughly the typical company in this group.

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Pricing Power

Developing
41

Where COYA ranks in Biotechnology

Coya Therapeutics, Inc. ranks #252 of 713 scored companies in Biotechnology by moat score — the top 35%. The widest moat in the group is Royalty Pharma plc (RPRX) at 85/100.

Moat scores for companies ranked near COYA in Biotechnology
# Company Moat score Rating
248 MediWound Ltd. MDWD 49/100 Developing
249 Agios Pharmaceuticals, Inc. AGIO 49/100 Developing
250 Palvella Therapeutics, Inc. PVLA 49/100 Developing
251 Syndax Pharmaceuticals, Inc. SNDX 49/100 Developing
252 Coya Therapeutics, Inc. COYA 49/100 Developing
253 Immuron Limited IMRN 49/100 Developing
254 Editas Medicine, Inc. EDIT 49/100 Developing
255 Generation Bio Co. GBIO 49/100 Developing
256 Barinthus Biotherapeutics plc BRNS 49/100 Developing

See every Biotech / Pre-Revenue company ranked by moat score →

How COYA scores on the Corporate Default defenses

Pricing Power

Score 41 · 20% of the moat score

Pricing power is the ability to raise prices without losing volume.

Cost Advantage

Score 59 · 15% of the moat score

A cost advantage means delivering the same product for structurally less — better purchasing, denser distribution, a more automated process.

Customer Stickiness

Score 67 · 15% of the moat score

Stickiness is what makes revenue repeat without being re-won every year.

Capital Efficiency

Score 28 · 18% of the moat score

Capital efficiency asks what the company earns on the money tied up in the business.

Resilience

Score 76 · 17% of the moat score

Resilience is the capacity to get through a bad year on its own terms — enough liquidity, enough interest cover, and enough cash generation to avoid a rescue financing or a forced sale.

Scale & Market Position

Score 35 · 15% of the moat score

Scale matters only when it converts into economics.

How each Corporate Default defense is measured, in full →

Understanding COYA's moat

What is Coya Therapeutics, Inc.'s moat score?

Coya Therapeutics, Inc. (COYA) scores 49 out of 100 on the StatsAlpha Moat Map, which rates its competitive advantage as developing. It ranks #252 of 713 scored companies in Biotechnology, the top 35%. The score is a weighted composite of 6 competitive defenses, each measured against industry peers of 712 companies in Biotechnology. Its strongest defense is Resilience (76/100) and its weakest is Capital Efficiency (28/100).

How does Coya Therapeutics, Inc. compare with other Biotechnology companies?

Coya Therapeutics, Inc. ranks #252 of 713 scored companies in Biotechnology by moat score. The widest moat in Biotechnology is Royalty Pharma plc (RPRX) at 85/100. The companies ranked closest are Syndax Pharmaceuticals, Inc. (SNDX) at 49 just above it and Immuron Limited (IMRN) at 49 just below it.

How is the moat score calculated?

Each company is scored with an industry-specific template — Corporate Default in this case, chosen because the defenses that matter to a bank are not the ones that matter to a software company. Every defense combines several financial signals, and each signal is measured as a percentile against a peer group of 712 companies in Biotechnology. The defenses are then weighted to produce the overall score out of 100.

Why is Coya Therapeutics, Inc. scored with the Corporate Default template?

Most public companies sell a product or a service at a margin, so the moat question is whether that margin survives contact with competitors. The Corporate template scores the six defenses that show up in a general operating company's financial signature: whether it can hold price, produce more cheaply than rivals, keep its customers, earn a return above its cost of capital, withstand a downturn, and turn size into economics.

Which competitive defenses are measured for Coya Therapeutics, Inc.?

The Corporate Default template measures 6 defenses, and COYA scores: Pricing Power (41), Cost Advantage (59), Customer Stickiness (67), Capital Efficiency (28), Resilience (76), Scale & Market Position (35). Each is scored independently as a percentile against peers, so a company can be strong on one and weak on another — the overall score reflects how those defenses are weighted for this industry.

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