MacroGenics, Inc., a clinical-stage biopharmaceutical company, discovers, develops, manufactures, and commercializes antibody-based therapeutics to treat cancer in the United States. The company's product pipeline includes lorigerlimab, a bispecific DART molecule that targets checkpoint inhibitors PD-1 and CTLA-4 for the treatment of mCRPC and docetaxel that is in phase 2 clinical trials, as well as for the treatment of platinum-resistant ovarian …
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Competitive advantage assessment
Key strengths
Cost Leadership PositionOperating margin at 77.1th percentile with strong OpEx control demonstrates cost leadership.
Strong Interest Coverage & Conservative LeverageDebt serviceability is strong (score 0.86), with robust interest coverage.
Key risks
ROIC Below WACC or PeersROIC at 24.1th percentile suggests inefficient capital deployment.
The dashed ring is the peer median. Defense scores are percentile ranks
against peers, so 50 is roughly the typical company in this group.
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MacroGenics, Inc. ranks #112 of 713
scored companies in Biotechnology by moat score — the top 16%.
The widest moat in the group is Royalty Pharma plc (RPRX)
at 85/100.
Moat scores for companies ranked near MGNX in Biotechnology
Pricing power is the ability to raise prices without losing volume.
Cost Advantage
Score 85
· 15% of the moat score
A cost advantage means delivering the same product for structurally less — better purchasing, denser distribution, a more automated process.
Customer Stickiness
Score 68
· 15% of the moat score
Stickiness is what makes revenue repeat without being re-won every year.
Capital Efficiency
Score 32
· 18% of the moat score
Capital efficiency asks what the company earns on the money tied up in the business.
Resilience
Score 75
· 17% of the moat score
Resilience is the capacity to get through a bad year on its own terms — enough liquidity, enough interest cover, and enough cash generation to avoid a rescue financing or a forced sale.
Scale & Market Position
Score 58
· 15% of the moat score
Scale matters only when it converts into economics.
MacroGenics, Inc. (MGNX) scores 60 out of 100 on the StatsAlpha Moat Map, which rates its competitive advantage as moderate. It ranks #112 of 713 scored companies in Biotechnology, the top 16%. The score is a weighted composite of 6 competitive defenses, each measured against industry peers of 712 companies in Biotechnology. Its strongest defense is Cost Advantage (85/100) and its weakest is Capital Efficiency (32/100).
How does MacroGenics, Inc. compare with other Biotechnology companies?
MacroGenics, Inc. ranks #112 of 713 scored companies in Biotechnology by moat score. The widest moat in Biotechnology is Royalty Pharma plc (RPRX) at 85/100. The companies ranked closest are Sarepta Therapeutics, Inc. (SRPT) at 60 just above it and ArriVent BioPharma, Inc. (AVBP) at 60 just below it.
How is the moat score calculated?
Each company is scored with an industry-specific template — Corporate Default in this case, chosen because the defenses that matter to a bank are not the ones that matter to a software company. Every defense combines several financial signals, and each signal is measured as a percentile against a peer group of 712 companies in Biotechnology. The defenses are then weighted to produce the overall score out of 100.
Why is MacroGenics, Inc. scored with the Corporate Default template?
Most public companies sell a product or a service at a margin, so the moat question is whether that margin survives contact with competitors. The Corporate template scores the six defenses that show up in a general operating company's financial signature: whether it can hold price, produce more cheaply than rivals, keep its customers, earn a return above its cost of capital, withstand a downturn, and turn size into economics.
Which competitive defenses are measured for MacroGenics, Inc.?
The Corporate Default template measures 6 defenses, and MGNX scores: Pricing Power (49), Cost Advantage (85), Customer Stickiness (68), Capital Efficiency (32), Resilience (75), Scale & Market Position (58). Each is scored independently as a percentile against peers, so a company can be strong on one and weak on another — the overall score reflects how those defenses are weighted for this industry.
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