Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which is in Phase 3 development; and SPR720, …
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Competitive advantage assessment
Key strengths
ROIC Sustainably Above PeersROIC at 84.8th percentile exceeds peers and WACC, demonstrating superior capital allocation.
Cost Leadership PositionOperating margin at 89.7th percentile with strong OpEx control demonstrates cost leadership.
Key risks
Commodity Pressure / Weak DifferentiationGross margin at 10.4th percentile with high volatility suggests weak pricing power or commoditized products.
Revenue Volatility Signals Weak StickinessRevenue volatility is high (stability score 0.17), suggesting weak customer stickiness.
The dashed ring is the peer median. Defense scores are percentile ranks
against peers, so 50 is roughly the typical company in this group.
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Spero Therapeutics, Inc. ranks #69 of 713
scored companies in Biotechnology by moat score — the top 10%.
The widest moat in the group is Royalty Pharma plc (RPRX)
at 85/100.
Moat scores for companies ranked near SPRO in Biotechnology
Pricing power is the ability to raise prices without losing volume.
Cost Advantage
Score 88
· 15% of the moat score
A cost advantage means delivering the same product for structurally less — better purchasing, denser distribution, a more automated process.
Customer Stickiness
Score 56
· 15% of the moat score
Stickiness is what makes revenue repeat without being re-won every year.
Capital Efficiency
Score 75
· 18% of the moat score
Capital efficiency asks what the company earns on the money tied up in the business.
Resilience
Score 74
· 17% of the moat score
Resilience is the capacity to get through a bad year on its own terms — enough liquidity, enough interest cover, and enough cash generation to avoid a rescue financing or a forced sale.
Scale & Market Position
Score 63
· 15% of the moat score
Scale matters only when it converts into economics.
Spero Therapeutics, Inc. (SPRO) scores 64 out of 100 on the StatsAlpha Moat Map, which rates its competitive advantage as moderate. It ranks #69 of 713 scored companies in Biotechnology, the top 10%. The score is a weighted composite of 6 competitive defenses, each measured against industry peers of 712 companies in Biotechnology. Its strongest defense is Cost Advantage (88/100) and its weakest is Pricing Power (34/100).
How does Spero Therapeutics, Inc. compare with other Biotechnology companies?
Spero Therapeutics, Inc. ranks #69 of 713 scored companies in Biotechnology by moat score. The widest moat in Biotechnology is Royalty Pharma plc (RPRX) at 85/100. The companies ranked closest are Adaptive Biotechnologies Corpor (ADPT) at 64 just above it and Xenetic Biosciences, Inc. (XBIO) at 64 just below it.
How is the moat score calculated?
Each company is scored with an industry-specific template — Corporate Default in this case, chosen because the defenses that matter to a bank are not the ones that matter to a software company. Every defense combines several financial signals, and each signal is measured as a percentile against a peer group of 712 companies in Biotechnology. The defenses are then weighted to produce the overall score out of 100.
Why is Spero Therapeutics, Inc. scored with the Corporate Default template?
Most public companies sell a product or a service at a margin, so the moat question is whether that margin survives contact with competitors. The Corporate template scores the six defenses that show up in a general operating company's financial signature: whether it can hold price, produce more cheaply than rivals, keep its customers, earn a return above its cost of capital, withstand a downturn, and turn size into economics.
Which competitive defenses are measured for Spero Therapeutics, Inc.?
The Corporate Default template measures 6 defenses, and SPRO scores: Pricing Power (34), Cost Advantage (88), Customer Stickiness (56), Capital Efficiency (75), Resilience (74), Scale & Market Position (63). Each is scored independently as a percentile against peers, so a company can be strong on one and weak on another — the overall score reflects how those defenses are weighted for this industry.
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