Calidi Biotherapeutics, Inc., a clinical stage immuno-oncology company, develops allogeneic stem cell-based and enveloped virus platforms to potentiate and deliver oncolytic viruses in the United States. Its product pipeline comprises CLD-101, which is in Phase 1b/2 clinical trial for the treatment of high-grade glioma, as well as in Phase 1 dose-escalation clinical trial for recurrent high-grade glioma; CLD-201 product for …
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Competitive advantage assessment
Key risks
Commodity Pressure / Weak DifferentiationGross margin at 31.7th percentile with high volatility suggests weak pricing power or commoditized products.
ROIC Below WACC or PeersROIC at 4.5th percentile suggests inefficient capital deployment.
The dashed ring is the peer median. Defense scores are percentile ranks
against peers, so 50 is roughly the typical company in this group.
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Calidi Biotherapeutics, Inc. ranks #638 of 713
scored companies in Biotechnology by moat score — the top 89%.
The widest moat in the group is Royalty Pharma plc (RPRX)
at 85/100.
Moat scores for companies ranked near CLDI in Biotechnology
Pricing power is the ability to raise prices without losing volume.
Cost Advantage
Score 5
· 15% of the moat score
A cost advantage means delivering the same product for structurally less — better purchasing, denser distribution, a more automated process.
Customer Stickiness
Score 8
· 15% of the moat score
Stickiness is what makes revenue repeat without being re-won every year.
Capital Efficiency
Score 6
· 18% of the moat score
Capital efficiency asks what the company earns on the money tied up in the business.
Resilience
Score 24
· 17% of the moat score
Resilience is the capacity to get through a bad year on its own terms — enough liquidity, enough interest cover, and enough cash generation to avoid a rescue financing or a forced sale.
Scale & Market Position
Score 19
· 15% of the moat score
Scale matters only when it converts into economics.
What is Calidi Biotherapeutics, Inc.'s moat score?
Calidi Biotherapeutics, Inc. (CLDI) scores 12 out of 100 on the StatsAlpha Moat Map, which rates its competitive advantage as weak. It ranks #638 of 713 scored companies in Biotechnology, the top 89%. The score is a weighted composite of 6 competitive defenses, each measured against industry peers of 712 companies in Biotechnology. Its strongest defense is Resilience (24/100) and its weakest is Cost Advantage (5/100).
How does Calidi Biotherapeutics, Inc. compare with other Biotechnology companies?
Calidi Biotherapeutics, Inc. ranks #638 of 713 scored companies in Biotechnology by moat score. The widest moat in Biotechnology is Royalty Pharma plc (RPRX) at 85/100. The companies ranked closest are Ensysce Biosciences, Inc. (ENSC) at 12 just above it and Applied Therapeutics, Inc. (APLT) at 12 just below it.
How is the moat score calculated?
Each company is scored with an industry-specific template — Corporate Default in this case, chosen because the defenses that matter to a bank are not the ones that matter to a software company. Every defense combines several financial signals, and each signal is measured as a percentile against a peer group of 712 companies in Biotechnology. The defenses are then weighted to produce the overall score out of 100.
Why is Calidi Biotherapeutics, Inc. scored with the Corporate Default template?
Most public companies sell a product or a service at a margin, so the moat question is whether that margin survives contact with competitors. The Corporate template scores the six defenses that show up in a general operating company's financial signature: whether it can hold price, produce more cheaply than rivals, keep its customers, earn a return above its cost of capital, withstand a downturn, and turn size into economics.
Which competitive defenses are measured for Calidi Biotherapeutics, Inc.?
The Corporate Default template measures 6 defenses, and CLDI scores: Pricing Power (10), Cost Advantage (5), Customer Stickiness (8), Capital Efficiency (6), Resilience (24), Scale & Market Position (19). Each is scored independently as a percentile against peers, so a company can be strong on one and weak on another — the overall score reflects how those defenses are weighted for this industry.
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