Precision BioSciences, Inc., a clinical stage gene editing company, develops in vivo gene editing therapies for gene edits, including gene insertion, excision, and elimination in the United States. The company offers ARCUS, a genome editing platform for DNA genome insertion, removal, and repair. It also provides PBGENE-HBV for the treatment of chronic hepatitis B virus (HBV) to eliminate covalently closed …
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Competitive advantage assessment
Key strengths
Margins Stable Across CyclesOperating margin volatility is low (stability score 0.83), demonstrating pricing resilience across cycles.
Scale Supporting ProfitabilityProfitability at scale is strong (score 0.83), demonstrating competitive advantages.
The dashed ring is the peer median. Defense scores are percentile ranks
against peers, so 50 is roughly the typical company in this group.
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Precision BioSciences, Inc. ranks #126 of 713
scored companies in Biotechnology by moat score — the top 18%.
The widest moat in the group is Royalty Pharma plc (RPRX)
at 85/100.
Moat scores for companies ranked near DTIL in Biotechnology
Pricing power is the ability to raise prices without losing volume.
Cost Advantage
Score 68
· 15% of the moat score
A cost advantage means delivering the same product for structurally less — better purchasing, denser distribution, a more automated process.
Customer Stickiness
Score 54
· 15% of the moat score
Stickiness is what makes revenue repeat without being re-won every year.
Capital Efficiency
Score 32
· 18% of the moat score
Capital efficiency asks what the company earns on the money tied up in the business.
Resilience
Score 72
· 17% of the moat score
Resilience is the capacity to get through a bad year on its own terms — enough liquidity, enough interest cover, and enough cash generation to avoid a rescue financing or a forced sale.
Scale & Market Position
Score 69
· 15% of the moat score
Scale matters only when it converts into economics.
Precision BioSciences, Inc. (DTIL) scores 58 out of 100 on the StatsAlpha Moat Map, which rates its competitive advantage as moderate. It ranks #126 of 713 scored companies in Biotechnology, the top 18%. The score is a weighted composite of 6 competitive defenses, each measured against industry peers of 712 companies in Biotechnology. Its strongest defense is Resilience (72/100) and its weakest is Capital Efficiency (32/100).
How does Precision BioSciences, Inc. compare with other Biotechnology companies?
Precision BioSciences, Inc. ranks #126 of 713 scored companies in Biotechnology by moat score. The widest moat in Biotechnology is Royalty Pharma plc (RPRX) at 85/100. The companies ranked closest are Agenus Inc. (AGEN) at 58 just above it and Structure Therapeutics Inc. (GPCR) at 58 just below it.
How is the moat score calculated?
Each company is scored with an industry-specific template — Corporate Default in this case, chosen because the defenses that matter to a bank are not the ones that matter to a software company. Every defense combines several financial signals, and each signal is measured as a percentile against a peer group of 712 companies in Biotechnology. The defenses are then weighted to produce the overall score out of 100.
Why is Precision BioSciences, Inc. scored with the Corporate Default template?
Most public companies sell a product or a service at a margin, so the moat question is whether that margin survives contact with competitors. The Corporate template scores the six defenses that show up in a general operating company's financial signature: whether it can hold price, produce more cheaply than rivals, keep its customers, earn a return above its cost of capital, withstand a downturn, and turn size into economics.
Which competitive defenses are measured for Precision BioSciences, Inc.?
The Corporate Default template measures 6 defenses, and DTIL scores: Pricing Power (58), Cost Advantage (68), Customer Stickiness (54), Capital Efficiency (32), Resilience (72), Scale & Market Position (69). Each is scored independently as a percentile against peers, so a company can be strong on one and weak on another — the overall score reflects how those defenses are weighted for this industry.
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